Wave modes excited by photospheric p-modes and mode conversion in a multi-loop system

Context. Waves are ubiquitous in the solar corona and there are indications that they are excited by photospheric p-modes. However, it is unclear how p-modes in coronal loops are converted to sausage modes and transverse (kink) modes, which are observed in the corona. Aims. We aim to investigate how those wave modes are excited in the lower corona by photospheric acoustic waves. Methods. We built 3D magnetohydrostatic loop systems with multiple inclinations spanning from the photosphere to the lower corona. We then simulated these atmospheres with the MANCHA code, in which we perturb the equilibrium with a p-mode driver at the bottom of the domain. By splitting the velocity perturbation into components longitudinal, normal, and azimuthal to the magnetic flux surfaces we can study wave behavior. Results. In vertical flux tubes, we find that deformed fast sausage surface waves and slow sausage body waves are excited. In inclined flux tubes fast kink surface waves, slow sausage body waves, and either a fast sausage surface wave or a plane wave are excited. In addition, we calculate a wave conversion factor (0 $\le$ C $\le$ 1) from acoustic to magnetic wave behavior by taking the ratio of the mean magnetic energy flux to the sum of the mean magnetic and acoustic energy flux and compare it to a commonly used theoretical conversion factor. We find that between magnetic field inclinations of 10$^\circ$ to 30$^\circ$ those two methods lie within 40%. For smaller inclinations the absolute deviation is smaller than 0.1.Comment: 14 pages, 14 figure

Cut-off of transverse waves through the solar transition region

Context. Transverse oscillations are ubiquitously observed in the solar corona, both in coronal loops and open magnetic flux tubes. Numerical simulations suggest that their dissipation could heat coronal loops, counterbalancing radiative losses. These models rely on a continuous driver at the footpoint of the loops. However, analytical works predict that transverse waves are subject to a cut-off in the transition region. It is thus unclear whether they can reach the corona, and indeed heat coronal loops. Aims. Our aims are to determine how the cut-off of kink waves affects their propagation into the corona, and to characterize the variation of the cut-off frequency with altitude. Methods. Using 3D magnetohydrodynamic simulations, we modelled the propagation of kink waves in a magnetic flux tube, embedded in a realistic atmosphere with thermal conduction, that starts in the chromosphere and extends into the corona. We drove kink waves at four different frequencies, and determined whether they experienced a cut-off. We then calculated the altitude at which the waves were cut-off, and compared it to the prediction of several analytical models. Results. We show that kink waves indeed experience a cut-off in the transition region, and we identified the analytical model that gives the best predictions. In addition, we show that waves with periods shorter than approximately 500 s can still reach the corona by tunnelling through the transition region, with little to no attenuation of their amplitude. This means that such waves can still propagate from the footpoints of loop, and result in heating in the corona.Comment: Accepted for publication in A&A. 8 pages, 7 figure

Finding the mechanism of wave energy flux damping in solar pores using numerical simulations

Context. Solar magnetic pores are, due to their concentrated magnetic fields, suitable guides for magnetoacoustic waves. Recent observations have shown that propagating energy flux in pores is subject to strong damping with height; however, the reason is still unclear. Aims. We investigate possible damping mechanisms numerically to explain the observations. Methods. We performed 2D numerical magnetohydrodynamic (MHD) simulations, starting from an equilibrium model of a single pore inspired by the observed properties. Energy was inserted into the bottom of the domain via different vertical drivers with a period of 30s. Simulations were performed with both ideal MHD and non-ideal effects. Results. While the analysis of the energy flux for ideal and non-ideal MHD simulations with a plane driver cannot reproduce the observed damping, the numerically predicted damping for a localized driver closely corresponds with the observations. The strong damping in simulations with localized driver was caused by two geometric effects, geometric spreading due to diverging field lines and lateral wave leakage.Comment: 12 pages (including appendix), 13 figures, accepted for publication by A&

Patterns of peripheral blood B-cell subtypes are associated with treatment response in patients treated with immune checkpoint inhibitors: a prospective longitudinal pan-cancer study

BACKGROUND: Immune checkpoint inhibitors (ICIs) have revolutionized systemic anti-tumor treatments across different types of cancer. Nevertheless, predictive biomarkers regarding treatment response are not routinely established yet. Apart from T-lymphocytes, the humoral immunity of B-lymphocytes is studied to a substantially lesser extent in the respective setting. Thus, the aim of this study was to evaluate peripheral blood B-cell subtypes as potential predictors of ICI treatment response. METHODS: Thirty-nine cancer patients receiving ICI therapy were included into this prospective single-center cohort study. All had a first blood draw at the date before treatment initiation and a second at the time of first response evaluation (after 8-12 weeks). Seven different B-cell subtypes were quantified by fluorescence-activated cell sorting (FACS). Disease control- (DCR) and objective response rate (ORR) were co-primary study endpoints. RESULTS: Overall, DCR was 48.7% and ORR was 25.6%, respectively. At baseline, there was no significant association of any B-cell subtype with neither DCR nor ORR. At the first response evaluation, an increase in the frequency of CD21(-) B-cells was a statistically significant negative predictor of response, both regarding DCR (OR=0.05, 95%CI=0.00-0.67, p=0.024) and ORR (OR=0.09, 95%CI=0.01-0.96, p=0.046). An increase of the frequency of switched memory B-cells was significantly associated with reduced odds for DCR (OR=0.06, 95%CI=0.01-0.70, p=0.025). Patients with an increased frequency of naïve B-cells were more likely to benefit from ICI therapy as indicated by an improved DCR (OR=12.31, 95%CI=1.13-134.22, p=0.039). CONCLUSION: In this study, certain B-cell subpopulations were associated with ICI treatment response in various human cancer types

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Search for stop and higgsino production using diphoton Higgs boson decays

Results are presented of a search for a "natural" supersymmetry scenario with gauge mediated symmetry breaking. It is assumed that only the supersymmetric partners of the top-quark (stop) and the Higgs boson (higgsino) are accessible. Events are examined in which there are two photons forming a Higgs boson candidate, and at least two b-quark jets. In 19.7 inverse femtobarns of proton-proton collision data at sqrt(s) = 8 TeV, recorded in the CMS experiment, no evidence of a signal is found and lower limits at the 95% confidence level are set, excluding the stop mass below 360 to 410 GeV, depending on the higgsino mass

Severe early onset preeclampsia: short and long term clinical, psychosocial and biochemical aspects

Preeclampsia is a pregnancy specific disorder commonly defined as de novo hypertension and proteinuria after 20 weeks gestational age. It occurs in approximately 3-5% of pregnancies and it is still a major cause of both foetal and maternal morbidity and mortality worldwide1. As extensive research has not yet elucidated the aetiology of preeclampsia, there are no rational preventive or therapeutic interventions available. The only rational treatment is delivery, which benefits the mother but is not in the interest of the foetus, if remote from term. Early onset preeclampsia (<32 weeks’ gestational age) occurs in less than 1% of pregnancies. It is, however often associated with maternal morbidity as the risk of progression to severe maternal disease is inversely related with gestational age at onset2. Resulting prematurity is therefore the main cause of neonatal mortality and morbidity in patients with severe preeclampsia3. Although the discussion is ongoing, perinatal survival is suggested to be increased in patients with preterm preeclampsia by expectant, non-interventional management. This temporising treatment option to lengthen pregnancy includes the use of antihypertensive medication to control hypertension, magnesium sulphate to prevent eclampsia and corticosteroids to enhance foetal lung maturity4. With optimal maternal haemodynamic status and reassuring foetal condition this results on average in an extension of 2 weeks. Prolongation of these pregnancies is a great challenge for clinicians to balance between potential maternal risks on one the eve hand and possible foetal benefits on the other. Clinical controversies regarding prolongation of preterm preeclamptic pregnancies still exist – also taking into account that preeclampsia is the leading cause of maternal mortality in the Netherlands5 - a debate which is even more pronounced in very preterm pregnancies with questionable foetal viability6-9. Do maternal risks of prolongation of these very early pregnancies outweigh the chances of neonatal survival? Counselling of women with very early onset preeclampsia not only comprises of knowledge of the outcome of those particular pregnancies, but also knowledge of outcomes of future pregnancies of these women is of major clinical importance. This thesis opens with a review of the literature on identifiable risk factors of preeclampsia